HUMAN GENOME MODIFICATIONS
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Forgot your password? Contains all of these words:. Filed Under Sequencing. Epigenetics Research. Genetic Research.
U.S. Food and Drug Administration
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By Synthego Cell Engineering Jul The report urges government to set up a new body to ensure that as many voices as possible are involved in public discussions about what should and should not be permissible. In the event that the law is changed, gene editing of human embryos should be considered on a case-by-case basis by the fertility regulator, the Human Fertilisation and Embryology Authority, the report adds. But Marcy Darnovsky at the Center for Genetics and Society in California said that the report recognised that if reproductive gene editing was permitted, it would be used for enhancement and cosmetic purposes.
For more information about CRISPR-Cas9 and other genome editing technologies:
Topics Science. Genetics Biology Ethics Gene editing news. Reuse this content. Any other application for example, genetic 'enhancement' should not be allowed to proceed at this time. This committee strongly recommended that the public be informed of progress already made in human genome editing as well as any future developments. We think it is especially important for scientists to make public education and outreach an integral part of their research and to have discussions with relevant parties, including members of the public, regulatory agencies and medical professionals.
It is critical that the social license to operate these technologies for therapy not be infringed by premature experimentation on heritable genome engineering for proof of principle or academic priority.
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The future safety of germline edits is an important area for research that we think can readily be explained to the public. Further, there are currently few genetic arguments for the necessity of correcting the genetic material of future generations given preimplantation diagnosis of monogenic conditions.
The ISSCR Statement on Human Germline Genome Modification
Therefore, we think it is imperative to discuss future concepts of genome editing that could be considered acceptable therapies. One might discuss a panel of deleterious mutations lacking compensating selective advantages that would be justified for multiplex removal from all in vitro —fertilized IVF embryos.
If germline editing technology could achieve this end routinely and safely, without genotypic discrimination, it would then be as ready for implementation as a panel of recommended vaccinations. One can be supportive of scientific advance and at the same time advise reasonable caution in the adoption of powerful new technologies.
Much more needs to be known about the safety and consequences of human germline genome editing before it can be considered for medical application.
Additionally, the motivation for adopting the technology, together with legal and ethical issues, needs to be thoroughly discussed and revisited as more information becomes available. Allowing for clinical trials to proceed in this area, under strict oversight and without regional loopholes in legislation, will help answer some outstanding questions and usher in this new era with forethought and responsibility.
To obtain permission to re-use content from this article visit RightsLink. Article metrics. Advanced search. Skip to main content. Subjects Gene targeting Targeted gene repair Translational research.